|Full name of organisation||Karolinska Institutet, Dept. Of Clinical Neuroscience|
|Position(s) description, department||
Dept. of Clinical Neuroscience, research intern
The student will work under the supervision of advanced PhD students or/and Postdocs in the group. The activities/tasks will include designing, performing, analyzing, interpreting and presenting experiments. The type of experiments will depend on the ongoing projects and will likely involve commonly used techniques such as PCR, qPCR, basic cloning, cell culture, in-vivo animal models, flow cytometry, CRISPR/Cas9, various methods to quantify DNA methylation and ncRNAs etc.
|Duration||Minimum period of 5 months|
|Language(s) of internship||Good knowledge of English language (spoken and written).|
|Other skills required||Basic skills (e.g. Microsoft Word, Excel, PowerPoint etc.). For those interested in bioinformatics analysis, basic skills in R are required.|
|Field of Education||Bachelor or Master in Biomedical Sciences or similar|
|General information about organisation||
Our research aims to characterize epigenetic mechanisms underlying neuroinflammation with the prospect of a better understanding chronic inflammatory diseases (mainly Multiple Sclerosis) and developing novel treatments and biomarkers. Epigenetic changes occur in response to internal and external environment and decide the timing and location of gene expression. This is mainly achieved through DNA methylation, histone modifications and action of nuclear factors and non-coding RNAs, which shape the 3D structure of genetic material.
Our focus is on DNA methylation and microRNAs. We investigate (i) epigenetic inheritance of inflammation, (ii) epigenetic landscape of inflammatory cells and inflamed tissues, (iii) genetic and environmental factors that control epigenetic states and (iv) regulatory mechanisms of microRNAs.
Center for Molecular Medicine, L8:04, Karolinska University Hospital
SE-171 76, Stockholm, Sweden